Publications

2017

A. Goryachev, M. Leda, Many roads to symmetry breaking: Molecular mechanisms and theoretical models of yeast cell polarity, Mol. Biol. Cell 28(3), 370 – 380 (2017).

2016

D. Mutavchiev, M. Leda, K. Sawin, Remodeling of the fission yeast Cdc42 cell-polarity module via the Sty1 p38 stress-activated protein kinase pathway, Curr. Biol. 26(21), 2921 – 2928 (2016).

A. Goryachev, M. Leda, Gradient sensing: Engineering yeast love affair, Curr. Biol. 26(11) R463 – R466 (2016).

A. Goryachev, M. Leda, A. Miller, G. von Dassow, W. Bement, How to make a static cytokinetic furrow out of propagating excitable waves, Small GTPases, 7(12), 65 – 70 (2016).

G. Vandin, D. Marenduzzo, A. Goryachev, E. Orlandini, Curvature-driven positioning of Turing patterns on phase-separating curved membranes, Soft Matter, 12(17), 3888 – 3896 (2016).

2015

W. Bement, M. Leda, A. Moe, A. Kita, M. Larson, A. Golding, C. Pfeuti, K-C. Su, A. Miller, A. Goryachev, G. von Dassow, Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium, Nature Cell Biol., 17(11), 1471 – 1483 (2015).

2014

C. Reyes, M. Jin, E. Breznau, R. Espino, R. Delgado-Gonzalo, A. Goryachev, A. Miller, Anillin regulates cell-cell junction integrity by organizing junctional accumulation of Rho-GTP and actomyosin, Curr. Biol. 24(11), 1263 – 1270 (2014).

A. Lichius, A. Goryachev, M. Fricker, B. Obara, E. Castro-Longoria, N. Read, CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa, J. Cell Sci., 127(9) 1953 – 1965 (2014).

K. Wolff, C. Barrett-Freeman, M. Evans, A. Goryachev, D. Marenduzzo, Modelling the effect of myosin X motors on filopodia growth, Physical Biology, 11(1) 016005 (2014).

2013

E. Orlandini, D. Marenduzzo, A. Goryachev, Domain formation on curved membranes: phase separation or Turing patterns? Sotf Matter, 9(39), 9311 - 9318 (2013).

S. Okada, M. Leda, J. Hanna, N. Savage, E. Bi, A. Goryachev, Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis. Dev. Cell, 26(2), 148 - 161 (2013).

2012

A. Goryachev, A. Lichius, G. Wright, N. Read, Excitable behavior can explain the "ping-pong" mode of communication between cells using the same chemoattractant. BioEssays, 34(4), 259 - 266 (2012).

N. Read, A. Goryachev, A. Lichius, The mechanistic basis of self-fusion between conidial anastomosis tubes during fungal colony initiation. Fungal Biol. Reviews, 6(1), 1 - 11 (2012).

2011

V. Kiselev, M. Leda, A. Lobanov, D. Marenduzzo, A. Goryachev, Lateral dynamics of charged lipids and peripheral proteins in spatially heterogeneous membranes: Comparison of continuous and Monte-Carlo approaches, J. Chem. Phys., 135, 155103 (2011).

A. Goryachev, A common mechanism for protein cluster formation, Small GTPases, 2(3), 143 - 147 (2011).

N. Zuleger, D. Kelly, A. Richardson, A. Kerr, M. Goldberg, A. Goryachev, and E. Schirmer, System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics, J. Cell Biology, 193(1), 109 - 123 (2011).

V. Kiselev, D. Marenduzzo, and A. Goryachev, Lateral dynamics of proteins with polybasic domoain on anionic membranes: A dynamic Monte-Carlo study, Biophys. J., 100(5), 1261 - 1270 (2011).

A. Goryachev, Understanding bacterial cell-cell communication with computational modeling, Chem. Rev., 111, 238 - 250 (2011).

2010

C. Bicho, D. Kelly, H. Snaith, A. Goryachev, and K. Sawin, A catalytic role for Mod5 in the formation of the Tea1 cell polarity landmark, Curr. Biology, 20(19), 1752 - 1757 (2010).

S. Teo, A. Goryachev, K. Parker, and K. Chiam, Cellular deformation and intracellular stress propagation during optical stretching, Phys. Rev. E 81, 051924 (2010).

2009

A. Howell, N. Savage, S. Johnson, I. Bose, A. Wagner, T. Zyla, H. Nijhout, M. Reed, A. Goryachev, and D. Lew, Singularity in polarization: re-wiring yeast cells to make two buds, Cell 139(4), 731 – 743 (2009).

N. Read, A. Lichius, J. Shoji, A. Goryachev, Self-signalling and self-fusion in filamentous fungi, Cur. Opinion in Microbiology, 12(6), 608 – 615 (2009).

A. Goryachev, Design principles of the bacterial quorum sensing gene networks. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 1(1), 45 - 60 (2009).

2008

M. Bass, M. Morgan, K. Roach, J. Settleman, A. Goryachev, M. Humphries, p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4. J. Cell Biology, 181(6), 1013 - 1026 (2008).

A. Goryachev, A. Pokhilko, Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Letters, 582(10), 1437 - 1443 (2008).

2007

B. Aguda, A. Goryachev, From pathway databases to network models of switching behavior. PLoS Computational Biology , 3(9), 1674 - 1678 (2007).

2006

A. Goryachev, A. Pokhilko, Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. PLoS Computational Biology, 2(12), 1511 - 1521: e172 (2006).

S. Ng, R. Han, S. Chang, W. Hunziker, A. Goryachev, H. Yu, Improved hepatocyte excretory function by immediate presentation of polarity cues. Tissue Engineering, 12(8), 2181 – 2191 (2006).

B. Schimmer, M. Cordova, H. Cheng, A. Tsao, A. Goryachev, A. Schimmer, Q. Morris, Global profiles of gene expression induced by ACTH in Y1 mouse adrenal cells. Endocrinology, 147(5), 2357 – 2367 (2006).

A. Goryachev , D.-J. Toh, T. Lee, Systems analysis of a quorum sensing network: design constraints imposed by the functional requirements, network topology and kinetic constants. BioSystems 83(2), 178 – 187 (2006).

2001 - 2005

A. Goryachev , D.-J. Toh, K. B. Wee, T. Lee, H. B. Zhang, and L. H. Zhang, Transition to quorum sensing in an Agrobacterium population: A stochastic model. PLoS Computational Biology 1(4), 265 – 275 (2005).

D.-J. Toh, F. Tang, T. Lee, D. Sarda, A. Krishnan, and A. Goryachev, Parallel computing platform for the agent-based modeling of multicellular biological systems. In: K. M. Liew, H. Shen, S. See, et al. (Eds.) Parallel and distributed computing: applications and technologies. (2004) Springer, Heidelberg.

L. Chen, A. Goryachev, J. Sun, P. Kim, H. Zhang, M. Phillips, P. Macgregor, S. Lebel, A. Edwards, and K. Furuya, Altered expression of genes involved in hepatic morphogenesis and fibrogenesis are identified by cDNA microarray analysis in biliary atresia. Hepatology. 38(3), 567 - 576 (2003).

A. Goryachev, P. Macgregor, and A. Edwards, Unfolding of microarray data. J. Comp. Biol. 8(4), 443 - 461 (2001).

K. Mossman, P. Macgregor, J. Rozmus, A. Goryachev, A. Edwards, and J. Smiley, Herpes simplex virus triggers and then disarms a host antiviral response. J. Virol. 75(2), 750 - 758 (2001).

1996 - 2000

S. Hemming, D. Jansma, P. Macgregor, A. Goryachev, J. Friesen, and A. Edwards, RNA polymerase II subunit Rpb 9 regulates transcription elongation in vivo. J. Biol. Chem. 275, 35506 - 35511 (2000).

A. Goryachev, R. Kapral, and H. Chate, Synchronization defect lines. Int. J. Bif. & Chaos 10, 1537 - 1564 (2000).

A. Goryachev, H. Chate, and R. Kapral, Transition to Line-Defect Mediated Turbulence in Complex Oscillatory Media. Phys. Rev. Lett. 83, 1878 - 1881 (1999).

A. Goryachev and R. Kapral, Spiral Waves in Media with Complex Excitable Dynamics. Int. J. Bif. & Chaos 9, 2243 - 2247 (1999).

A. Goryachev, H. Chate, and R. Kapral, Synchronization Defects and Broken Symmetry in Spiral Waves. Phys. Rev. Lett. 80, 873 - 876 (1998).

A. Goryachev, P. Strizhak, and R. Kapral, Slow Manifold Structure and the Emergence of Mixed-Mode Oscillations. J. Chem. Phys. 107, 2881 - 2889 (1997).

A. Goryachev and R. Kapral, Structure of Complex-Periodic and Chaotic Media with Spiral Waves. Phys. Rev. E 54, 5469 - 5482 (1996).

A. Goryachev and R. Kapral, Spiral Waves in Chaotic Systems. Phys. Rev. Lett. 76, 1619 - 1622 (1996).

A. Goryachev, A. Polezhaev, and D. Chernavskii, Catastrophic Extinction, Noise-Stabilized Turbulence and Unpredictability of Competition in Modified Volterra-Lotka Model. CHAOS 6, 78 - 86 (1996).