2024
D. Cebrian-Lacasa, M. Leda, A. Goryachev, L. Gelens, Wave-driven phase wave patterns in a ring of FitzHugh-Nagumo oscillators. Phys. Rev. E. 110(5), 054208, (2024). 
A. Goryachev, M. Leda, Actomyosin cortex: Inherently oscillatory? Curr. Biol., 34(14), R675–R696, (2024).
W. Bement, A. Goryachev, A. Miller, G. von Dassow, Patterning of the cell cortex by Rho GTPases. Nat. Rev. Mol. Cell Biol., 25(4), 290 - 308, (2024).
2023
K. Lavrsen, G. Rajendraprasad, M. Leda, S. Elbes, E. Vitiello, V. Katopodis, A. Goryachev, M. Barisic, Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration. PNAS, 120(22):e2300322120, (2023).
2022
A. Michaud, M. Leda, Z. Swider, S. Kim, J. He, J. Valley, J. Huisken, J. Landino, A. Goryachev, G. von Dassow, W. Bement, A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2, and RGA-3/4. J. Cell Biol., 221(8):e202203017, (2022).
Z. Swider, A. Michaud, M. Leda, J. Landino, A. Goryachev, W. Bement, Cell cycle and developmental control of cortical excitability in Xenopus laevis. Mol. Biol. Cell, 33(8), (2022).
S. Varadarajan, S. Chumki, R. Stephenson, E. Misterovich, J. Wu, C. Dudley, I. Erofeev, A. Goryachev, A. Miller, Mechanosensitive calcium flashes promote sustained RhoA activation during tight junction remodeling, J. Cell Biol., 221(4), e202105107 (2022).
2021
J. Landino, M. Leda, A. Michaud, Z. Swider, M. Prom, C. Field, W. Bement, A. Vecchiarelli, A. Goryachev, A. Miller, Rho and F-actin self-organize within an artificial cell cortex, Curr. Biol., 31(24), 5613 - 5621 (2021).
A. van Loon, I. Erofeev, A. Goryachev, A. Sagasti, Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells, Mol. Biol. Cell, 32(16), 1501 - 1513 (2021).
A. Michaud, Z. Swider, J. Landino, M. Leda, A. Miller, G. von Dassow, A. Goryachev, W. Bement Cortical excitability and cell division, Curr. Biol., 31(10), R553 (2021).
A. Dünkler, M. Leda, J.-M. Kromer, J. Neller, T. Gronemeyer, A. Goryachev, N. Johnsson, Type V myosin focuses the polarisome and shapes the tip of yeast cells, J. Cell Biol., 220(5), e202006193 (2021).
A. Goryachev, Symmetry breaking as an interdisciplinary concept unifying cell and developmental biology, Cells, 10(1), 86, (2021).
2020
A. Goryachev, M. Mallo, Patterning and morphogenesis from cells to organisms: Progress, common principles and new challenges, Frontiers in Cell and Deveopmental Biology, 8, 602483 (2020).
A. Goryachev, M. Leda, Compete or coexist? Why the same mechanisms of symmetry breaking can yield distinct outcomes, Cells, 9(9), E2011 (2020).
I. Maryshev, A. Morozov, A. Goryachev, D. Marenduzzo, Pattern formation in active model C with anchoring: bands, aster networks and foams, Soft Matter, 16(38), 8775 - 8781 (2020).
A. van Loon, I. Erofeev, I. Maryshev, A. Goryachev, A. Sagasti, Cortical contraction drives the 3D patterning of epithelial cell surfaces, J Cell Biol, 219(3), e201904144 (2020).
2019
A. Goryachev, M. Leda, Autoactivation of small GTPases by the GEF-effector positive feedback modules, F1000 Research, 8, 1676 (2019).
I. Maryshev, A. Goryachev, D. Marenduzzo, A. Morozov, Dry active turbulence in a model for microtubule-motor mixtures, Soft Matt., 25(30), 6038 – 6043 (2019).
A. Kita, Z. Swider, I. Erofeev, M. Halloran, A. Goryachev, W. Bement, Spindle-F-actin interactions in mitotic spindles in an intact vertebrate epithelium, Mol. Biol. Cell, 30(14), 1645 – 1654 (2019).
R. Stephenson, T. Higashi, I. Erofeev, T. Arnold, M. Leda, A. Goryachev, A. Miller, Rho flares repair local tight junction leaks, Dev. Cell, 48(4), 445 – 459 (2019).
Y. Tay, M. Leda, C. Spanos, J. Rappsilber, A. Goryachev, K. Sawin, Fission yeast NDR/LATS kinase Orb6 regulates exocytosis via phosphorylation of the exocyst complex, Cell Rep., 26(6), 1654 – 1667 (2019).
2018
M. Leda, A. Holland, A. Goryachev, Autoamplification and competition drive symmetry breaking: Initiation of centriole duplication by the PLK4-STIL network, iScience, 8, 222 – 235 (2018).
Y. Tay, M. Leda, A. Goryachev, K. Sawin, Local and global Cdc42 GEFs for fission yeast cell polarity are coordinated by microtubules and the Tea1/Tea4/Pom1 axis, J. Cell Sci., 131(14) pii: jcs216580 (2018).
I. Maryshev, D. Marenduzzo, A. Goryachev, A. Morozov, Kinetic theory of pattern-formation in mixtures of microtubules and molecular motors, Phys. Rev. E, 97(2), 022412 (2018).
2017
A. Goryachev, M. Leda, Cell Polarity: Spot-on Cdc42 polarization achieved on demand, Curr. Biol. 27(16), R796 – R815 (2017).
A. Goryachev, M. Leda, Many roads to symmetry breaking: Molecular mechanisms and theoretical models of yeast cell polarity, Mol. Biol. Cell 28(3), 370 – 380 (2017).
2016
D. Mutavchiev, M. Leda, K. Sawin, Remodeling of the fission yeast Cdc42 cell-polarity module via the Sty1 p38 stress-activated protein kinase pathway, Curr. Biol. 26(21), 2921 – 2928 (2016).
A. Goryachev, M. Leda, Gradient sensing: Engineering yeast love affair, Curr. Biol. 26(11) R463 – R466 (2016).
A. Goryachev, M. Leda, A. Miller, G. von Dassow, W. Bement, How to make a static cytokinetic furrow out of propagating excitable waves, Small GTPases, 7(12), 65 – 70 (2016).
G. Vandin, D. Marenduzzo, A. Goryachev, E. Orlandini, Curvature-driven positioning of Turing patterns on phase-separating curved membranes, Soft Matter, 12(17), 3888 – 3896 (2016).
2015
W. Bement, M. Leda, A. Moe, A. Kita, M. Larson, A. Golding, C. Pfeuti, K-C. Su, A. Miller, A. Goryachev, G. von Dassow, Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium, Nature Cell Biol., 17(11), 1471 – 1483 (2015).
2014
C. Reyes, M. Jin, E. Breznau, R. Espino, R. Delgado-Gonzalo, A. Goryachev, A. Miller, Anillin regulates cell-cell junction integrity by organizing junctional accumulation of Rho-GTP and actomyosin, Curr. Biol. 24(11), 1263 – 1270 (2014).
A. Lichius, A. Goryachev, M. Fricker, B. Obara, E. Castro-Longoria, N. Read, CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa, J. Cell Sci., 127(9) 1953 – 1965 (2014).
K. Wolff, C. Barrett-Freeman, M. Evans, A. Goryachev, D. Marenduzzo, Modelling the effect of myosin X motors on filopodia growth, Physical Biology, 11(1) 016005 (2014).
2013
E. Orlandini, D. Marenduzzo, A. Goryachev, Domain formation on curved membranes: phase separation or Turing patterns? Sotf Matter, 9(39), 9311 - 9318 (2013).
S. Okada, M. Leda, J. Hanna, N. Savage, E. Bi, A. Goryachev, Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis. Dev. Cell, 26(2), 148 - 161 (2013).
2012
A. Goryachev, A. Lichius, G. Wright, N. Read, Excitable behavior can explain the "ping-pong" mode of communication between cells using the same chemoattractant. BioEssays, 34(4), 259 - 266 (2012).
N. Read, A. Goryachev, A. Lichius, The mechanistic basis of self-fusion between conidial anastomosis tubes during fungal colony initiation. Fungal Biol. Reviews, 6(1), 1 - 11 (2012).
2011
V. Kiselev, M. Leda, A. Lobanov, D. Marenduzzo, A. Goryachev, Lateral dynamics of charged lipids and peripheral proteins in spatially heterogeneous membranes: Comparison of continuous and Monte-Carlo approaches, J. Chem. Phys., 135, 155103 (2011).
A. Goryachev, A common mechanism for protein cluster formation, Small GTPases, 2(3), 143 - 147 (2011).
N. Zuleger, D. Kelly, A. Richardson, A. Kerr, M. Goldberg, A. Goryachev, and E. Schirmer, System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics, J. Cell Biology, 193(1), 109 - 123 (2011).
V. Kiselev, D. Marenduzzo, and A. Goryachev, Lateral dynamics of proteins with polybasic domoain on anionic membranes: A dynamic Monte-Carlo study, Biophys. J., 100(5), 1261 - 1270 (2011).
A. Goryachev, Understanding bacterial cell-cell communication with computational modeling, Chem. Rev., 111, 238 - 250 (2011).
2010
C. Bicho, D. Kelly, H. Snaith, A. Goryachev, and K. Sawin, A catalytic role for Mod5 in the formation of the Tea1 cell polarity landmark, Curr. Biology, 20(19), 1752 - 1757 (2010).
S. Teo, A. Goryachev, K. Parker, and K. Chiam, Cellular deformation and intracellular stress propagation during optical stretching, Phys. Rev. E 81, 051924 (2010).
2009
A. Howell, N. Savage, S. Johnson, I. Bose, A. Wagner, T. Zyla, H. Nijhout, M. Reed, A. Goryachev, and D. Lew, Singularity in polarization: re-wiring yeast cells to make two buds, Cell 139(4), 731 – 743 (2009).
N. Read, A. Lichius, J. Shoji, A. Goryachev, Self-signalling and self-fusion in filamentous fungi, Cur. Opinion in Microbiology, 12(6), 608 – 615 (2009).
A. Goryachev, Design principles of the bacterial quorum sensing gene networks. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 1(1), 45 - 60 (2009).
2008
M. Bass, M. Morgan, K. Roach, J. Settleman, A. Goryachev, M. Humphries, p190RhoGAP is the convergence point of adhesion signals from α5β1 integrin and syndecan-4. J. Cell Biology, 181(6), 1013 - 1026 (2008).
A. Goryachev, A. Pokhilko, Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity. FEBS Letters, 582(10), 1437 - 1443 (2008).
2007
B. Aguda, A. Goryachev, From pathway databases to network models of switching behavior. PLoS Computational Biology , 3(9), 1674 - 1678 (2007).
2006
A. Goryachev, A. Pokhilko, Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. PLoS Computational Biology, 2(12), 1511 - 1521: e172 (2006).
S. Ng, R. Han, S. Chang, W. Hunziker, A. Goryachev, S. Ong, H. Yu, Improved hepatocyte excretory function by immediate presentation of polarity cues. Tissue Engineering, 12(8), 2181 – 2191 (2006).
B. Schimmer, M. Cordova, H. Cheng, A. Tsao, A. Goryachev, A. Schimmer, Q. Morris, Global profiles of gene expression induced by ACTH in Y1 mouse adrenal cells. Endocrinology, 147(5), 2357 – 2367 (2006).
A. Goryachev , D.-J. Toh, T. Lee, Systems analysis of a quorum sensing network: design constraints imposed by the functional requirements, network topology and kinetic constants. BioSystems 83(2), 178 – 187 (2006).
2001 - 2005
A. Goryachev , D.-J. Toh, K. B. Wee, T. Lee, H. B. Zhang, and L. H. Zhang, Transition to quorum sensing in an Agrobacterium population: A stochastic model. PLoS Computational Biology 1(4), 265 – 275 (2005).
D.-J. Toh, F. Tang, T. Lee, D. Sarda, A. Krishnan, and A. Goryachev, Parallel computing platform for the agent-based modeling of multicellular biological systems. In: K. M. Liew, H. Shen, S. See, et al. (Eds.) Parallel and distributed computing: applications and technologies. (2004) Springer, Heidelberg.
L. Chen, A. Goryachev, J. Sun, P. Kim, H. Zhang, M. Phillips, P. Macgregor, S. Lebel, A. Edwards, and K. Furuya, Altered expression of genes involved in hepatic morphogenesis and fibrogenesis are identified by cDNA microarray analysis in biliary atresia. Hepatology. 38(3), 567 - 576 (2003).
A. Goryachev, P. Macgregor, and A. Edwards, Unfolding of microarray data. J. Comp. Biol. 8(4), 443 - 461 (2001).
K. Mossman, P. Macgregor, J. Rozmus, A. Goryachev, A. Edwards, and J. Smiley, Herpes simplex virus triggers and then disarms a host antiviral response. J. Virol. 75(2), 750 - 758 (2001).
1996 - 2000
S. Hemming, D. Jansma, P. Macgregor, A. Goryachev, J. Friesen, and A. Edwards, RNA polymerase II subunit Rpb 9 regulates transcription elongation in vivo. J. Biol. Chem. 275, 35506 - 35511 (2000).
A. Goryachev, R. Kapral, and H. Chate, Synchronization defect lines. Int. J. Bif. & Chaos 10, 1537 - 1564 (2000).
A. Goryachev, H. Chate, and R. Kapral, Transition to Line-Defect Mediated Turbulence in Complex Oscillatory Media. Phys. Rev. Lett. 83, 1878 - 1881 (1999).
A. Goryachev and R. Kapral, Spiral Waves in Media with Complex Excitable Dynamics. Int. J. Bif. & Chaos 9, 2243 - 2247 (1999).
A. Goryachev, H. Chate, and R. Kapral, Synchronization Defects and Broken Symmetry in Spiral Waves. Phys. Rev. Lett. 80, 873 - 876 (1998).
A. Goryachev, P. Strizhak, and R. Kapral, Slow Manifold Structure and the Emergence of Mixed-Mode Oscillations. J. Chem. Phys. 107, 2881 - 2889 (1997).
A. Goryachev and R. Kapral, Structure of Complex-Periodic and Chaotic Media with Spiral Waves. Phys. Rev. E 54, 5469 - 5482 (1996).
A. Goryachev and R. Kapral, Spiral Waves in Chaotic Systems. Phys. Rev. Lett. 76, 1619 - 1622 (1996).
A. Goryachev, A. Polezhaev, and D. Chernavskii, Catastrophic Extinction, Noise-Stabilized Turbulence and Unpredictability of Competition in Modified Volterra-Lotka Model. CHAOS 6, 78 - 86 (1996).